Objective: To study the absorption characteristics of notoginsenoside R1 influenced by density

energy and p-glycoprotein with rat non-everted gut sac system. Method: Different concentration of notoginsenoside R1 was immersed into rat non-everted gut sac

and the absorption difference was compared.2-nitropenol

a metabolic inhibitor

was used to study the influence of energy on the absorption of notoginsenoside R1.Verapamil

a p-glycoprotein inhibitor

was used to study the influence of p-glycoprotein on the absorption of notoginsenoside R1. Result: The notoginsenoside R1 concentration in the sac was increasing according to the time.It was obvious that 2-nitropenol affected the absorption of notoginsenoside R1.Verapamil had no effect on the absorption of notoginsenoside R1 in sac system. Conclusion: The absorption mechanism of notoginsenoside R1 might be passive diffusion.Notoginsenoside R1 might not be the substrate of p-glycoprotein.