Objective : To study the bacteriostatic effects of Belamcanda chinensis extract in vitro and in vivo. Method : Inhibition zone diameters were measured to investigate the bacteriostatic effects of B.chinensis extract on various germ strains

and to identify the sensitive strains to B.chinensis extract;Minimal inhibitory concentrations (MIC)of B.chinensis extract was determined by double-fold dilution method. Bacteriostatic effect of B.chinensis extract in vivo was determined in the mice model with peritoneal injection of Staphylococcus aureus. Result : Streptococcus pneumoniae and Pseudomonas aeruginosa were more sensitive to B.chinensis extract than S.aureus

Bacillus coli

Streptococcus agalactiae

Micrococcus scarlatinae and Shigella dysenteriae.MIC of S.aureus

S.pneumoniae

B.coli

P.aeruginosa

S.agalactiae

M.scarlatinae and S.dysenteriae were 0.062 5

0.015 6

0.250 0

0.031 2

0.015 6

0.015 6

0.062 5 g ·mL-1

respectively.After mice were administrated low-

medium-or high-dose(0.46

0.92

1.82 g ·kg-1)of B.chinensis extract ig for 7 days

the mortality of mice injected S.aureus and yeast suspension were 45%

35%

30% respectively. Conclusions : B.chinensis extract has bacteriostatic activity in vitro and in vivo.