Objective: Using in vitro everted gut scas to investigate the intestinal absorption of the extracts from Corydalis yanhusuo at different intestinal section and different concentration. Method: Corydaline (CDL) and Tetrahydropalmatine (THP) which are representative compositions of the extracts from Corydalis yanhusuo in everted gut scas were detected by HPLC

and the absorption parameter to describe the character of absorption was calculated. Result: The absorption of CDL and THP was linearity in different intestine and different dose

and the square of coefficient correlation exceed 0.95

which consistent with zero order rate process. The Ka of CDL and THP increased along with the raised dosage of the extracts from Corydalis yanhusuo (P<0.05)

indicated the passive absorption. The absorption of CDL or THP in duodenum

jejunum

ileum was quick

but the absorption of CDL or THP in colon absorption was slow. And the absorption of THP was quicker than that of CDL. Conclusion: For different dosage of extracts from Corydalis yanhusuo

the absorption of CDL and THP conforms to the zero order rate process at different sections of intestine

with a pattern of passive absorption.