Objective: To study the preparation method for baicalin microcapsule using gelatin gum as sealing materials. Method: Baicalin microcapsule was prepared by simple coacervation method. The uniform design was adopted to optimize the preparation procedure with drug loading as evaluation indexes. Result: The optimum preparation technique of baicalin microcapsule was: the ratio of core material to coating material was 1 ∶2; the temperature of encapsulation was at 45 ℃ and the stirring speed was 550 r ·min-1. Conclusion: The results showed that baicalin microcapsule had appropriate diameter

distribution of microcapsule particles size and the dissolution meets the requirements.