Objective: To study the time-quantity relationship of index components of Huanglian Jiedu(HLJD) and its connection with the effect in ischemic brain injury in rats with syndrome of fire-heat after oral of Huanglian Jiedu decoction. Method: By electrocoagulation established model of focal cerebral ischemia with syndrome of fire-heat

after treatment group were orally administered Huanglian Jiedu decoction

catch blood at different time are as followes

0.083

0.25

0.5

0.75

1

2

3

4

6

8

12

24 h

determination of index components in rats draw the time-quantity curve; Catched brains at the points mentioned above

determinated the changes of IL-6

TNF-α

and draw the time-effect curve. Combined with time-quantity curve and time-effect curve

evaluate the function of index components in Huanglian Jiedu decoction treat ischemic disease with Syndrome of fire-heat. Result: Pharmacokinetics of index components of HLJD are different

which have a effect on its pharmacodynamics. Geniposide made a marked effect at prophase times after administration

while baicalin and baicalein made a lasting effect. Conclusion: Huanglian Jiedu decoction to play anti-ischemic brain with syndrome of fire-heat injury

the function connected with index components relevant content in the body

different components producted various time bar.