Objective: To study the renal protective effects of Qidan Yishen Jiangtang Capsule (QYJC)in diabetic nephropathy rats. Method: The DN rats model was established by one side nephrectomy and intraperitoneal injection of streptozotocin.Then rats were randomly divided into 3 groups: sham-operation group

model group

QYJC group

10 in each group.Rats were given the relevant drugs respectively for 12 weeks.Finally the levels of body weight (BW)

fasting blood glucose (FBG)

blood urea nitrogen (BUN)

serum creatine (SCr)

albumin (ALB)

total cholesterol (TC)

triglyceride (TG)

24-hour urinary protein excretion (UPE)were detected.The kidney tissue was taken for histopathological observation and lesion grade. Result: QYJC decreased the levels of FBG

BUN

TC

TG

UAE significantly (P ＜0.05 or 0.01)

it also reduced glomerulosclerosis index ( P <0.05 or 0.01)and tubulointerstitial fibrosis index ( P <0.05 or 0.01)as compared with DN model group. Conclusion : QYJC has a good renal protective effect in rats with diabetic nephropathy.The mechanism may be related to relieving blood lipid metabolism disorders.