Objective: The case data of 219 patients with Sap complicated with multiple organ dysfunction syndrome(MODS)admitted to general surgery department were retrospectively analyzed

to summarize the pattern of pathological changes and experience of prevention and integrated Chinese and Western medicine treatment in early organ function impairment of severe acute pancreatitis(SAP). Method: All patients with SAP received integrated Chinese and Western medicine treatment.After enrollment

the patients were given monitoring immediately.Based on the diagnostic procedures in accordance with MODS standard

the incidence of organ dysfunction at different time periods(1

3

7

10 and 14 days)were recorded and the incidence of organ dysfunction of SAP were recorded and analyzed. Result: In all the 219 cases

from high to low order

the incidence of organ impairment was that of the lung

circulation

kidney

heart

coagulation

brain

liver

metabolism. Severe conplications included acute respiratory distress syndrome in 46 cases(21％)

renal failure in 23 cases(10.5％)

shock in 17 cases(7.7％)

coagulation disorder in 12cases(5.5％)

gastrointestinal bleeding in 10cases(4.6％)

liver damage in 3 cases (1.4％)

and pancreatic encephalopathy in 2 cases(0.9％). After integrated Chinese and western medicine treatment

In the whole group

190 cases survived and 29 cases died

and the mortality was 13.2％. Conclusion: The organ impairment SAP characterized as that of the lung

kindey

circulation. Death had a close relation with acute respiratory distress syndrome

acute renal failing and shock.The prevention and treatment of multiple organ failure caused by SAP with integrated Chinese and Western medicine would be satisfactory effective.