Glucocorticoid is an effective medicine to cure inflammatory disease in clinic

but the glucocorticoid resistance always takes place. Modern medicine thinks that the resistance has relevant with glucocorticoid metabolism

the gene change of glucocorticoid receptor and the histone acetylase and deacetylases of target gene

etc. On the other hand

Traditional Chinese medicine regards the resitance related with the yin and yang deficit of kidney. This review is to summarize the pathogenesis progress of glucocorticoid resistance in both modern medicine and traditional chinese medicine.