Objective: To investigate the effects of Tengcha extract(TF)on hepatofibrosis induced by chronic hepatic injury. Method: Wistar rats were randomized into six groups: TF treatment (200

100 and 50 mg ·kg-1) groups

colchicines treatment(Colc

0.1 mg ·kg-1)group

model group and normal control group. Rats were injected carbon tetrachloride (CCl4) subcutaneously two times a week to induce hepatofibrosis as well as ig administration of TF or colchicines. After 10 weeks

the levels of alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

alkaline phosphatase(AKP)

albumin(ALB)

globulin (GLB) in serum and hydroxyproline(Hyp)

malondialdehyde(MDA)

glutathione peroxidase(GSH-Px) in liver tissue were determined

and liver histological changes were investigated by hematoxylin-eosin(HE) staining. Result: Compared with model group

TF significantly reduced the levels of ALT

AST

AKP and GLB in serum(P<0.01)

and decreased Hyp

MDA level in liver tissue (P<0.05)while ALB

A/G

GSH-Px were elevated significantly(P<0.01). Pathological examination revealed that TF had therapeutical effect on experimental hepatofibrosis. Conclusion: TF has better effects on protecting hepatocyte

relieving liver injury and against hepatofibrosis.