Objective: To study the intestinal absorption of the different match-pair of Coptis-Evodia

to compare the intestinal absorption rate and absorption coefficient. Method: Single pass perfusion models in rats and HPLC were used to study the concentration and absorption coefficients of match-pair of Coptis-Evodia

to study the absorption and transport in the small intestine. Result: The absorption rate of Coptis-Evodia 6 ∶6 were the largest in jejunum as Coptis-Evodia 6 ∶1 were the largest in Jejunum and Ileum

the difference was significant (P<0.05).The Ka of Coptis-Evodia 1 ∶1 in jejunum

kleum and colon was larger than that in Duodenum as the Kapp was the largest in ileum;the absorption rate of Coptis-Evodia 2 ∶1 and 6 ∶1 in ileum were larger than the other intestine

the difference was significant (P<0.05).The absorption rate of Coptis-Evodia 2 ∶1 in lleum were larger than the other match-pair

the difference was significant (P<0.05). Conclusion: Coptis-Evodia 1 ∶1 and 6 ∶1 were better absorpted in jejunum and ileum

Coptis-Evodia 2 ∶1 was better absorpted in ileum.