Objective: To establish the quality standard for Ganfukang tablets. Method: Hedyotis difusa and Pseudostellaria were identified by TLC. Schisandrin was determinated by HPLC. The chromatographic condition was as follows: column of Agilent HC-C18 (4.6 mm×250 mm

5 μm)

mobile phase consisting of acetonitrile-H2O (55 ∶45)

flow rate of 1.0 mL ·min-1

and detection wavelength of 250 nm. Ferrous sulphate was determinated by spectrophotometry. Result: The characteristic identification by TLC was distinct and highly specific. Schisandrin was linear in the range of 0.112-5.644 μg (r=0.999 98)

the average recovery was 97.03% (RSD 1.38%) with precision RSD of 1.5% (n=6)

repetition RSD of 1.65% (n=6) and stability RSD of 1.43%. Conclusion: The method is reliable

accurate

specific and can be used for quality control of the production.