Objective: To determine the contents of Zn

Cu

Fe

Co

Mn and Cr in Chinese medicine of Liuwei Dihuangwan by atomic absorption spectrometry

studying on the relationship between the trance elements and the composition of Liuwei Dihuangwan. Method: The factor analysis was used to investigate the relationship between the trance elements and the principle of Liuwei Dihuangwan composition and indication by the guiding of Chinese medicine. Result: Factor analysis revealed the two structure of Liuwei Dihuangwan

pointed out that efficacy of Fructus Rehmanniae Praeparata

Fructus corni

Rhizoma dioscoreae and Fe

Cr

Co

Mn function correlation; that efficacy of Poria

Cortex moutan

Rhizoma alismatis and Zn

Cu function correlation.The composition of Chinese medicine in prescription and arrange in dimensional affect were same as the complaining of Chinese medicine. Conclustion: The principle and indication of Chinese medicine are related to trance elements.