The alzheimer disease (AD) pathological models were collected to provide new ideas and methods

including main methods for establishing AD model

i.e. the physical methods

the chemical methods the multi-factors methods

transgenic AD model and natural aging AD model. From the data

we realized that there were many kinds of methods for AD establishment. Each model either at whole animal level or at cellular level has its advantages and disadvantages

with different underline mechanisms. Researchers should select the suitable method according to the need of their experiments.