Objective: The experimental study aims to study the pharmacodynamics of Xiangyan Zhitong decoction in primary dysmenorrheal therapy

we observed the pain-releasing effects of Xiangyan Zhitong decoction on dysmenorrheal in mouse and rat models induced by oxytocin. Changes of PGE2 and PGF2α content in rat peripheral blood and uterus tissues were measured

which could provide the pharmacological basis for clinical application of Xiangyan Zhitong decoction. Method: Dysmenorrheal was induced by diethylstilbestrol and oxytocin in mouse and rat with aspirin as the control

and the effectss of Xiangyan Zhitong decoction were observed for releasing oxytocin-induced pain and on PGE2 and PGF2α expression in rat peripheral blood and uterus tissue. Result: Xiangyan Zhitong decoction significantly inhibited the pain reactions in mice and rats induced by oxytocin. The content of PGE2 increased obviously in rat peripheral blood and uterus tissue

while PGF2αdecreased significantly. TCM group showed better effectiveness.Conclusions: Xiangyan Zhitong decoction could raise pain threshold and change the secretion of PGE2 and PGF2α. It has anti-dysmenorrheal effects.