DUAN Yan-bing, LIU Shi, LU Xiao-he. Synthesis of Antiplatelet Drug Triflusal [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 80-81.
DUAN Yan-bing, LIU Shi, LU Xiao-he. Synthesis of Antiplatelet Drug Triflusal [J]. Chinese journal of experimental traditional medical formulae, 2011, 17(7): 80-81.DOI:
Objective: To synthesis of the antiplatelet drug triflusal. Method: Triflusal was prepared from 4-trifluoro methyl salicylic acid by one step. Result: Its structure was confirmed by NMR
MS
IR
EA. The total yield of triflusal with the purity of 99.5% by HPLC was 65.4%. Conclusion: The synthetic route for triflusal was simple
feasible and convenient for industrial manufacture.