Objective: To investigate the effects of Huangjin capsule on insulin resistance in type 2 diabetic rats and the primary pharmacological mechanism. Method: The model of type 2 diabetic-insulin-resistant rats (T\-2DIRR) was made through intraperitonea injection of lower dosage of streptozocin(30 mg ·kg-1) and high caloric diet (abounded with sugar & fat)

the effects of Huangjin capsule on weight

blood and serum contents of glucose

TC

TG

HDL-C

observed in the model rats. Result: Huang jin capsule lowered significantly fasting blood glucose (FBG) and improved HDL-C; and reduced the TC

TG in T\-2DM

IR

and reduced the concentration of insulin in hyperinsulinemia

and potentiated ISI (P<0.01) in T\-2DM

IR. Conclusion: In the experiment with type 2 diabetic-insulin-resistant rats

huang jin capsule can lower fasting blood glucose (FBG) and reduce level of TC

TG

and improve HDL-C

insulin sensitivity.