Objective: To prepare pomegranate polyphenols gel and control the quality and to observe penetrability of gallic acid from the gel in vitro. Method: Carbopol-940 was used as the gel matrix

glycerin as wetting agent

potassium sorbate as a preservative and triethanolamine as neutralizer. UV-spectrometry method was used to determine total polyphenol content of the gel. The skin of rat was put between the supplying container and receiving container

and the experimentation of penetrating was carried out. Result: The preparing technology of gels was feasible. Gallic acid can be completely separated within a linear range of 0.024 5-0.245 0 g ·L-1(r=0.999 6). The average recovery was 99.56％

RSD 0.58％. The rate of penetrability in Gallic acid is 36.95％ during 24 hours. Conclusion: The preparation technique is simple and feasible for the quality control. It shows excellent transdermal effects.