Objective: To evaluate the quality and study the stability of Zhibing in-situ gel nasal-cavity. Method: High performance liquid chromatography (HPLC) was used to determine the content of imperatorin and isoimperatorin.Viscometer was used to determine the viscocity of gel.Displacement method was used to determine the adhesive force of gel.Valia-chien diffusion method was used to study the membrane permeation characteristics in vitro.In vitro dissolution method was used to study the in vitro release characteristics;pH meter was used to determine the phase-transition pH.Centrifuge method

heat proof and cold-resistant method

exposure method and room temperature retained sample observation method were used to study the stability of gel. Result: The content of active component was stable.The viscocity and adhesive force

the permeability coefficient

the in vitro release and the phase-transition pH were all in line with the rules of The Pharmacopoeia of the PRC (edition 2005). Conclusion: The quality of Zhibing in-situ gel nasal-cavity is stable;there is little difference among groups.