Objective: To investigate the anti-inflammatory and pain-relieving effect and mechanism of three extractives of Evodia lepta(Spr.) Merr. Method: The pain models were induced by acetic acid

the hot-plate tests

the Swelling auricles caused by Xylol and swelling paws induced by dextran in mice were used to observe the pain-relieving and anti-inflammatory effects

the spectrophotometric and fluorometric method and The enzyme linked immuno sorbent assay were used separately to measure prostaglandin E2(PGE2) in inflammatory tissue and cyclooxygenase-2(COX-2)in serum. Result: There was significant difference between four types of models and the negative control group in 2 extractives of E.lepta. Conclusion: E.lepta has effect of anti-inflammation and analgesia. The anti-inflammation function may be related to its suppression of and PGE2

COX-2.