Objective: To investigate the effect of "TCM prescription for Reinfocing Pi Qi"on regulating the kinase of nuclear factor-kappa B inhibitor β(IKKβ) and the level of interleukin 8 (IL-8) in asthmatic rats’lung tissue. Method: SPF male wistar rats were randomly divided into normal control group(A)

asthmatic group(B)and therapeutic group of "TCM prescription for reinfocing Pi Qi"(C).Asthmatic model was established via sensitizing and provoking ovalbumin.Rats of the C group were taken medicine ig once a day in 10 g ·kg-1 for 21 days.The protein expression level of mRNA of IKKβ in lung tissue was determined by Polymerase Chain Reaction (RT-PCR);the level of interleukin eight (IL-8) was detected in bronchoalveolar lavage fluid (BALF) by enzymes linked immunosorbent assay(ELISA). Result: ① The expression of mRNA of IKKβ in lung tissue in B group was significantly higher than that in A group and C group(P＜0.01 and P＜0.05 respectively).②The expression of protein of IKKβ in lung tissue in B group was significantly higher than that in A group and C group(P＜0.01).③ The level of IL-8 in BALF in B group was significantly higher than that in A group and C group(P＜0.01). Conclusion: "TCM prescription for reinfocing Pi Qi" inhibits IKKβ expression and reduce the level of IL-8.