复方地黄对老年痴呆动物模型学习记忆能力的影响

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复方地黄对老年痴呆动物模型学习记忆能力的影响

更新时间：2024-01-04

- 复方地黄对老年痴呆动物模型学习记忆能力的影响
- Effects of Compound Rehmannia on Learning and Memory Abilities in Senile Dementia Mice Induced by -galactose
- 中国实验方剂学杂志 2011年17卷第3期页码：195-197
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- 纸质出版日期：2011
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杨斌. 复方地黄对老年痴呆动物模型学习记忆能力的影响[J]. 中国实验方剂学杂志, 2011,17(3):195-197.

YANG Bin. Effects of Compound Rehmannia on Learning and Memory Abilities in Senile Dementia Mice Induced by -galactose[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 195-197.
杨斌. 复方地黄对老年痴呆动物模型学习记忆能力的影响[J]. 中国实验方剂学杂志, 2011,17(3):195-197. DOI：

YANG Bin. Effects of Compound Rehmannia on Learning and Memory Abilities in Senile Dementia Mice Induced by -galactose[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 195-197. DOI：

摘要

目的 :探讨复方地黄对 D -半乳糖致老年痴呆小鼠模型的学习记忆能力的影响及其机制。方法 :sc10% D -半乳糖6周建立小鼠老年痴呆模型

然后用复方地黄3.37

1.75g \5kg-1 ig 4周

对照组和模型组给予等量生理盐水。用Y型迷宫检测小鼠的学习记忆能力

同时检测小鼠脑组织一氧化氮(NO)含量以及超氧化物歧化酶(SOD)的活性。结果: 与空白组相比

模型组小鼠学习能力降低(p＜0.01)。给予小鼠高剂量复方地黄后

小鼠上述变化明显改善

与模型组相比差异具有统计学意义(p＜0.01)。结论 :复方地黄可改善 D -半乳糖致痴呆小鼠模型的学习记忆能力

其机制可能与复方地黄能使小鼠脑组织中NO含量降低和SOD活性升高有关。

Abstract

Objective: To study the effects of compound rehmannia on learning and memory abilities in senile dementia mice induced by D-galactose. Method: The senile dementia model mice were established by D-galactose hypodermic injection for 6 weeks and then given compound rehmannia in therapeutic group and the same volume of normal saline in the control. The learning and memory ability of all mice were test with Y-type maze

Nitric oxide (NO) and Superoxide dismutase(SOD) in brain were determined afterward. Result : Compared with control group

the learning and memory abilities in model group were lowered (P＜0.01). After given compound rehmannia all the abilities were significantly improved (P＜0.01). Conclusion: compound rehmannia can improve the leaning and memory abilities.

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