Objective: To observe the effects of Quzhi Baogan Granules on the rat’s fatty liver. Method: The rat’s fatty liver was induced by high fat diet. The different groups were given different drugs

to observe the efficacy of Quzhi Baogan Granules on the rat’s fatty liver

meanwhile to investigate the mechanism of the granules on the rat’s fatty liver. Result: Compared with blank control group

liver tissue CHO

TG levels in the models were increased significantly(P<0.01)

serum AST

ALT were significantly increased(P<0.01). Pathological investigation showed that liver cell steatosis was took place associated with cell injury and necrosis. Compared with model group

the liver tissue CHO

TG levels in the Quzhi Baogan high-dose group

mid-dose group

low-dose group were decreased obviously( P <0.01 or P <0.05)

the serum AST

ALT were decreased obviously( P <0.01 or P <0.05)

meanwhile the liver injury were alleviated. Conclusion: Quzhi Baogan Granules can reduce liver cell injury through the antioxidant mechanism

it can prevent and treat the rat’s fatty liver induced by high fat diet.