四磨汤对慢性应激小鼠多巴胺受体D1,D2的影响

刘柏炎; 易健; 蔺晓源; 易跃能; 蔡光先

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四磨汤对慢性应激小鼠多巴胺受体D1,D2的影响

更新时间：2024-01-04

- 四磨汤对慢性应激小鼠多巴胺受体D1,D2的影响
- Effects of Simo Decoction on Expression of Dopamine Receptor 1,2 in Brain and Duodenum Tissue in Chronic Stress Mice
- 中国实验方剂学杂志 2011年17卷第3期页码：192-194
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家重点基础研究计划(973)课题(2009CB523002);湖南省中医药科技计划项目(209004)
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- 纸质出版日期：2011
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刘柏炎, 易健, 蔺晓源, 等. 四磨汤对慢性应激小鼠多巴胺受体D1,D2的影响[J]. 中国实验方剂学杂志, 2011,17(3):192-194.

LIU Bai-yan, YI Jian, LIN Xiao-yuan, et al. Effects of Simo Decoction on Expression of Dopamine Receptor 1,2 in Brain and Duodenum Tissue in Chronic Stress Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 192-194.
刘柏炎, 易健, 蔺晓源, 等. 四磨汤对慢性应激小鼠多巴胺受体D1,D2的影响[J]. 中国实验方剂学杂志, 2011,17(3):192-194. DOI：

LIU Bai-yan, YI Jian, LIN Xiao-yuan, et al. Effects of Simo Decoction on Expression of Dopamine Receptor 1,2 in Brain and Duodenum Tissue in Chronic Stress Mice[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 192-194. DOI：

摘要

目的 :研究四磨汤对慢性应激小鼠多巴胺受体1

2 (DR1

DR2)的影响

明确四磨汤治疗功能性胃肠病(FGIDs)的作用机制。方法 :动物随机分组

采用饥饱失常、明暗颠倒以及束缚夹尾等多种方法造模

分别给予蒸馏水、多潘立酮、四磨汤(7.56 mL \5kg-1)治疗

免疫组织化学法观察小鼠脑内和肠道组织DR1

DR2的表达。结果 : 模型组小鼠脑内和十二指肠组织中DR1

DR2的表达增加

与正常组比较有统计学差异( P <0.05);四磨汤组DR1

DR2的表达下降

与模型组比较差异有统计学意义( P＜0.05)。结论 :四磨汤调节多巴胺受体D1

D2的表达

可能是其治疗功能性胃肠病的作用机制之一。

Abstract

Objective: To study effects of Simo decoction on expression of dopamine receptor 1

2(DR1

DR2) in brain and duodenum tissue in chronic stress mice. Method: The mice were randomly divided into control group

stress only (model) group

mosapride group and Simo decoction oral liquid (7.56 mL \5kg-1) group.Chronic stress model was established by exerting the factors of irregular diet

reverse of day and night

binding and stimulating tails. And then treated with distilled water

domperidone and Simo decoction. The expressions of DR1 and DR2 were measured by immunohistochemistry . Result: Simo decoction significantly enhanced expressions of DR1 and DR2 in brain and duodenum tissue compared with the normal group( P＜0.05).and there was significantly difference with model group P＜0.05). Conclusion: Simo decoction appears potential to regulate the expression of DR1 and DR2 in brain and duodenum tissue

which is one of possible mechanism to therapy FGIDs.

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