Objective: To study the interventive affect and mechanism of Buyang Huanwu decoction (BYHW decoction) on von Willebrand factor (vWF) of animal with metabolic syndrome(MetS). Method: Rats were distributed randomly into 4 groups: empty control

model control

BYHW decoction group

BYHW decoction without Astragali Radix group. To set up pathological modal of MetS

rats were given streptozotocin (STZ) and feed with high-fat and high-carbohydrate diet. Dose: BYHW decoction group 7.02 g ·kg-1 ig

BYHW decoction without Astragali Radix group 1.07 g ·kg-1 ig. Both were once a day. Experiment lasts for 8 weeks. Fasting blood glucose (FBG)

insulin(Ins)

homeostasis model assessment-insulin resistance(HOMA-IR) and vWF in serum were observed. Result: Compared with blank control

Ins

HOMA-IR and vWF were higher in model group (P<0.05). Compared with model

BYHW decoction group was lower in Ins

HOMA-IR and vWF(P<0.05); BYHW decoction without Astragali Radix group was higher in FBG (P<0.01)

no evident differences in Ins

HOMA-IR

and lower in vWF. Conclusion: BYHW decoction might prevent IR and reduce vWF. Astragali Radix is the effective part in preventing IR and six other drugs may reduce vWF.