Objective: To copy the rabbit model of necrosis of the femoral head

observe the number of osteoclasts

study the feasibility and mechanism of intramedullary injection with Salvia miltiorrhiza injection for preventing of steroid-induced necrosis of the femoral head at the molecular level. Method: Thirty rabbits were randomly divided into three groups: control group

model group

prevention group

10 in each group. Glucocorticoid-induced rabbit model of femoral head necrosis was prepared. While making the models

the prevention group has received bone marrow cavity intramedullary injection with Salvia miltiorrhiza. at a dose of 0.4 mg ·kg-1 twice a week for 8 weeks. 8 weeks later

the number of osteoclasts and histopathological changes in three groups of rabbits were observed. Result : The prevention group could effectively reduce the number of osteoclasts and the rate of empty lacunae femoral head. Conclusion : Salvia miltiorrhiza injection plays a good effective role in the prevention of steroid-induced avascular necrosis of femoral head through inhibitting osteoclast formation.