ObJective: To investigate in vivo nasal mucosa absorption of baicalin and its phospholipid complex in rats; to compare the effect of the baicalin-phospholipid complex on cerebral edema and neurological impairment by sublingual iv administration and intranasal administration. Method: The nasal absorption in vivo in rats was used to compare the intranasal absorption of baicalin and its phospholipid complex.The model of focal ischemic reperfusion inJury of middle cerebral artery was built in rats by placing an intraluminal suture and the prevention and treatment of baicalin phospholipid complex was observed after sublingual iv administration and intranasal administration. Result: The nasal mucosa absorption rate of baicalin-phospholipid complex in rat is significantly greater than that of baicalin

they are (12.2±2.04)×10-3 ·min-1 and(9.60±1.34)×10-3 ·min-1 accordingly. The neurologic function scores are 1.66±0.68 and 1.78±0.78 respectively. They manifest that prevention and treatment effect of baicalin-phospholipid complex by intranasal administration was better than by that of sublingual iv administration against cerebral edema and neurological impairment caused by cerebral ischemic inJury in rats. Moreover

the fresh content of brain tissue is (79.10±0.65)% and (79.48±0.76)% separately. Conclusion: The in vivo absorption and efficacy of baicalin-phospholipid complex was better than that of baicalin

and nasal intranasal administration is superior to sublingual iv administration.