Objective: To observe the post-stroke depression(PSD) model of rat and hippocampal neuronal apoptosis related gene expression changes

and the intervention of Bupleurum Liver-Coursing Powder on for PSD and the molecular mechanism. Method: One hundred male SD rats were randomly divided into the following 3 groups:Bupleurum Liver-Coursing Powder group

PSD model control group and normal control group. Except the normal control group

at first the other two groups were set up middle cerebral artery occlusion(MCAO) rat model

eneurological recovery of stroke rat was assessed by Longa grades standard test. A week after surgery

we re-establish PSD composite rat model

while Bupleurum Liver-Coursing Powder group (7.875 g \5kg-1) was fed 21 days with the drugs

PSD model control group was fed distilled water.Immunohistochemical staining detect Bcl-2 and Bax protein expression in hippoca mpus. Result: Compared with the normal control group

Bax protein expression in PSD model group was increased

but Bcl-2 protein decreased(P<0.01); Compared with the PSD model group

Bupleurum Liver-Coursing powder group was significantly reduced in Bax protein expression (P<0.01) and increased in Bcl-2 protein expression (P<0.01). Conclusion: Bupleurum Liver-Coursing Powder may play a role in the treatment of PSD through inhibiting the apoptosis by means of intervention with reduced Bax protein expression and increased the expression of Bcl-2 gene.