黄芪多糖对高血压病血瘀证患者血清损伤的人脐静脉内皮细胞形态学、活性的影响

张竞之; 陈利国; 贾会欣; 胡小勤

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黄芪多糖对高血压病血瘀证患者血清损伤的人脐静脉内皮细胞形态学、活性的影响

更新时间：2024-01-04

- 黄芪多糖对高血压病血瘀证患者血清损伤的人脐静脉内皮细胞形态学、活性的影响
- Effects of Astragalus Polysaccharide on Activity and Morphological Changes in HUVEC Induced by Serum from Patients with Blood Stasis Syndrome and Hypertension
- 中国实验方剂学杂志 2010年16卷第16期页码：170-173
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目(30572289);广东省自然科学基金项目(5006019)
- DOI：
  中图分类号：
- 纸质出版日期：2010
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张竞之, 陈利国, 贾会欣, 等. 黄芪多糖对高血压病血瘀证患者血清损伤的人脐静脉内皮细胞形态学、活性的影响[J]. 中国实验方剂学杂志, 2010,16(16):170-173.

ZHANG Jing-zhi, CHENG Li-guo, JIA Hui-xin, et al. Effects of Astragalus Polysaccharide on Activity and Morphological Changes in HUVEC Induced by Serum from Patients with Blood Stasis Syndrome and Hypertension[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 170-173.
张竞之, 陈利国, 贾会欣, 等. 黄芪多糖对高血压病血瘀证患者血清损伤的人脐静脉内皮细胞形态学、活性的影响[J]. 中国实验方剂学杂志, 2010,16(16):170-173. DOI：

ZHANG Jing-zhi, CHENG Li-guo, JIA Hui-xin, et al. Effects of Astragalus Polysaccharide on Activity and Morphological Changes in HUVEC Induced by Serum from Patients with Blood Stasis Syndrome and Hypertension[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 170-173. DOI：

摘要

目的: 观察黄芪多糖(astragalus polysaccharide

APS)对高血压病血瘀证患者血清损伤的人脐静脉内皮细胞(HUVEC-C)形态学、活性的影响。方法: 将培养的高血压病血瘀证患者血清损伤的HUVEC-C分别用不同浓度的APS含药血清干预后

倒置显微镜下观察其形态学变化

MTT法检测其活性。结果: APS呈剂量依赖性升高损伤的细胞OD值

且随着药物组浓度的增加

细胞的形态趋向正常细胞。结论: APS能够抵抗高血压病血瘀证患者血清中有害因子对HUVEC-C的损伤作用

能增强细胞的活性和维持细胞的形态结构

并呈剂量依赖性。

Abstract

Objective: To observe the effects of Astragalus Polysaccharide (APS) on activity and morphological Changes in human umbilical vein endothelial cells (HUVEC) induced by serum from patients with blood stasis syndrome (BSS) and hypertension. Method: The HUVEC was affected by the serum of the patient with BSS associated with hypertension and different dosage of APS was applied for intervention.The activity of the HUVEC was determined by MTT assay and the morphological changes were observed by the inverse phase contrast microscope. Result: APS had the protective effect for lightening the HUVEC shape change affected by the serum from patient of BSS associated with hypertension and the activity was increased in a dose-dependent manner. Conclusion: APS can lighten the injury of the HUVEC affected by the serum from the patient of BSS associated with hypertension

increase cells activity and maintenance for the normal shape of the cells.

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