ObJective: To study the protection effects of Swertia pseudochinensis Hara extract on experimental liver inJury. Method: Mouse model of acute liver inJury was established by ip inJection of 0.1% carbon tetrachloride (CCl4) oil solution (0.01 mL ·g-1)

and D -Galactosamine ( D -Gal

800 mg ·kg-1) respectively. Rat model of acute Jaundice was developed by ip inJection of α-naphthyl isothiocyanate oil solution (ANIT

100 mg ·kg-1). Several doses of S. pseudochinensis Hara extract were ig administrated to the models. Activity of alanine aminotransferase (ALT)

aspartate aminotransferase (AST) and total bilirubin (TBIL)

direct bilirubin (DBIL) Content in serum were determined. Bile flow in rats and pathological changes in liver were also investigated. Result: S. pseudochinensis Hara extract at the concentration of 92.6 mg ·kg-1inhibitted the acute liver inJury induced by CCl4 and D -Gal in mice. It decreased the increasing level of transaminases caused by ANIT in rat Jaundice model

and reduced the liver degeneration and the number and extent of necrosis in the model animals. The extract also increased the bile flow rate in the rat Jaundice model. Conclusion: S. pseudochinensis Hara extract has the efficacy of protecting liver from inJury to a certain extent.