LIU Xin-jun, SU Shi-bing, WANG Xiu-feng, et al. Effects of Bixue Capsule on Hemorheological Changes in Rats with Acute Blood Stasis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 174-176.
LIU Xin-jun, SU Shi-bing, WANG Xiu-feng, et al. Effects of Bixue Capsule on Hemorheological Changes in Rats with Acute Blood Stasis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 174-176.DOI:
Objective: To investigate the effects of Bixue Capsule on hemorheological changes in a rat model of acute blood stasis. Method: Sixty SD rats were divided at random into normal control group
model control group
Tongxinluo Capsule control groups
Low dose group
middle dose groups and high dose group (242
48
968 mg \5kg-1 accordingly) of Bixue Capsule. Rats were treated with oral medication daily for 7 days. The acute blood stasis was induced by subcutaneous injection of large dose of adrenaline hydrochloride and ice-water socking for the rats. Then
the hemorheological parameters were observed for evaluating the effects of Bixue Capsule. Result: As compared with vehicle
Bixue Capsule obviously decreased the low shear viscosity of whole blood
the hematocrit and erythrocyte aggregation (P<0.05). Conclusion: Bixue Capsule significantly reduced the degree of red blood cells aggregation and improved blood viscosity in rats with blood stasis syndrom.