大黄酚微囊的制备及其体外释药的研究

严春临; 张季; 张丹参; 张力; 薛贵平; 王树

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大黄酚微囊的制备及其体外释药的研究

更新时间：2024-01-04

- 大黄酚微囊的制备及其体外释药的研究
- Study on Preparation of Chrysophanol Microcapsule and its in vitro Release Behavior
- 中国实验方剂学杂志 2011年17卷第3期页码：7-10
- 作者机构：
- 作者简介：
- 基金信息：
  
  河北省卫生厅医学科学研究重点课题指导项目(08348)
- DOI：
  中图分类号：
- 纸质出版日期：2011
- 稿件说明：
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严春临, 张季, 张丹参, 等. 大黄酚微囊的制备及其体外释药的研究[J]. 中国实验方剂学杂志, 2011,17(3):7-10.

YAN Chun-lin, ZHANG Ji, ZHANG Dan-shen, et al. Study on Preparation of Chrysophanol Microcapsule and its in vitro Release Behavior[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 7-10.
严春临, 张季, 张丹参, 等. 大黄酚微囊的制备及其体外释药的研究[J]. 中国实验方剂学杂志, 2011,17(3):7-10. DOI：

YAN Chun-lin, ZHANG Ji, ZHANG Dan-shen, et al. Study on Preparation of Chrysophanol Microcapsule and its in vitro Release Behavior[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(3): 7-10. DOI：

摘要

目的 :研究大黄酚微囊的制备工艺。方法 :以包封率为指标

用正交设计法对大黄酚的制备工艺进行研究

对制备的微囊进行体外释药、形态、稳定性研究。结果 :用复凝聚法制备的大黄酚微囊

其囊心囊材比、搅拌速度及成囊温度均有显著性差异

当囊心囊材比为 1 ∶4

搅拌速度为200 r ·min-1

成囊温度为60 ℃时

包封率最高

囊径最小。结论: 该法制备工艺简单、可靠

产品稳定性好

具有一定的缓释效果。

Abstract

Objective: To study the preparation technique of chrysophanol microcapsules. Method: The preparation technique of chrysophanol microcapsules was optimized by orthogonal design; in vitro release of chrysophanol microcapsules

morphology and its stability were studied. Result: With the complex agglutination method

the encapsulation rate was significantly related to the ratio of coating material

the encapsulation temperature and the stirring speed. The highest rate of production and minimum diameter of microcapsule were obtained when the ratio of coating material to chrysophanol was 1 ∶4

the temperature of encapsulation was at 60 ℃ and the stirring speed was 200 r ·min-1. Conclusion: The process was simple and reliable. The chrysophanol microcapsules were very stable and could be used as sustained-release preparation.

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