Objective: To study the effects of Ginkgo biloba extract on renal hypertension rats (RHR). The serum nitric oxide (NO) content and the content of superoxide dismutase (SOD)

maleic disldehyde (MDA) in heart

brain and kidney tissue were investigated. Method: With the method of 2K1C

RHR were established and then the RHR were divided into five groups based on their blood pressure:blank group

model group

G.biloba extract high

middle

low dosage group and captopril group (n=8

each). Systolic blood pressure(SBP) and diastolic blood pressure(DBP) were measured respectively before therapy and two weeks

four weeks

six weeks

eight weeks after therapy. The serum content of NO and MDA

SOD in heart

brain and kidney were measured after eight weeks of therapy. Result: After eight weeks treatment

G.biloba extract significantly declined the pressure of RHR. captopril group and G.biloba extract high group had no significant difference. The two groups both increased the serum of NO and SOD in heart

brain and kidney

declined the MDA. Conclusion: The anti-hypertensive function of G.biloba extract may be related to NO

and protect target organ via antioxidation.