ObJective: To study the pharmacodynamic actions of Jingangteng's effective ingredients(JEIS) on chronic pelvic inflammation disease (CPID)and to provide experimental evidence for Jingangteng's further development. Method: The models of CPID were made by inJection of brei admixed with phenol and tragacanth into the uterus of rats

and the inhibitory effect on CPID was observed. The severity of oedema in inflammation was observed to study the anti-inflammatory effects of JEIS. The analgesic effect of the drug was studied with pain model of mice induced by acetic acid

the PGE2 contents in the uterus in CPID rats were measured by enzyme-linked immunosorbent assay (ELISA). Result: JEIS could obviously inhibit the inflammation of uterus in rats with CPID. The number of stretching induced by acetic acid was reduced and the pain threshold of mice was increased by JEIS. JEIS also had anti-inflammatory activity against xylene-induced mouse ear swelling and albumen-induced rat paw edema. JEIS could significantly decrease the level of PGE2

in the uterus of CPID rats. Conclusion: JEIS has significant analgesic and anti-inflammatory activities

and decreasing of PGE2 may be one of the anti-inflammation mechanisms of JEIS.