Objective: To study the influence of turtles and deer antlers granula on learning and memory in the natural aging mice. Method: The natural aging of 14 months mice were randomly divided into model control group

administration control group and the positive control group. Drugs was prepared in drinking water and administrated to the rats for consecutive 3 months. In addition

2 month-old mice were used as the young control group. Wrong and escape response latencies with step-down test for each group was investigated 4 days before the last administration. Two days before the last administration the error response latency and error response times within 5 min was detected by avoiding dark method. After the treatment of drugs

blood serum and brain homogenate were separated and prepared

superoxide dismutase (SOD)

glutathione peroxidase (GSH-Px) activity and malondialdehyde (MDA ) content was detected. Result: Compared with young control group error response latency of aged model group mice was significantly shorter

escape response latency was significantly longer

the error reaction times increased significantly

SOD

GSH-Px activity significantly decreased

MDA content increased significantly. Compared with the aging model group

error response latency of the administration control group aged mice was significantly prolonged

escape response latency was significantly shortened

error response rate was significantly decreased

SOD

GSH-Px activities were significantly increased

MDA content was significantly lower. Conclusion: The turtle and deer antlers granula can enhance antioxidant and improve learning and memory for the natural aging mice.