Objective: To explore the effect of XueluoFuxin granula on carotid artery thrombosis in rats and mesenteric microcirculation disturbance in mice. Method: Wistar rats were randomly divided into six groups according to body weight: normal control group

XueluoFuxin groups (5.2

10.4

20.8 g ·kg-1 ·d-1 crude herb)

Fufang Xueshuantong group (0.4 g ·kg-1 ·d-1) and troxerutin group (48.6 mg ·kg-1 ·d-1). Rats were given drugs ig everyday for 7 days. The right common carotid arteries of anesthetized rats were separated to observe the thromboembolism events at 30 minutes after the last administration. Mice were randomly divided into normal control group

XueluoFuxin groups (7.5

15.0

30.0 g ·kg-1 ·d-1 crude herb)

Danlou tablet group (0.58 g ·kg-1 ·d-1) and racanisodamine group (3.9 mg ·kg-1 ·d-1). Mice were given drugs ig for 7 days. Adrenaline was locally given on jejunal loops to induce mesenteric microcirculation disturbance at 30 min after the last administration. Micrangium diameter

blood flow rate in micrangium and hemorheology were observed. Result: XueluoFuxin reduced the thromboembolism events; accelerated the blood flow rate in micrangium and improved hemorheology. Conclusion: XueluoFuxin has the effects of inhibiting thrombosis and improving microcirculation.