ObJective: To explore the possibility for application of the ultrafiltration technology using polysulfone (PS) hollow fiber membrane to purify water-extraction of Lonicera and optimize the preparation procedure. Method: The PS membrane of different aperture 50 000

10 000 and 6 000 were studied on the applicability with water-extraction of Lonicera. The proper molecular weight retention was optimized with removal of liquid impurities and the transformation ratio of luteolin and chlorogenic acid as index

while the proper ultrafiltration condition was optimized by orthogonal tests. Result: The PS membrane with 10 000 interception molecular weight had better separation efficiency and the preferred operation parameters were 0.1 MPa of pressure

30 ℃ of liquid temperature

and 2.5 L ·min-1 of liquid speed. Conclusion: The preferred aperture of PS membrane and the operati on conditions are feasible for the purification of water-extraction of Lonicera

which can effectively improve the production efficiency.