ObJective: To study the effect and mechanism of Qizhi Tongluo Capsule assisted with aspirin on experimental cerebral ischemia-reperfusion inJury of rats. Method: The middle-cerebral-artery-occlusion(MCAO) was used to induce focal cerebral ischemia-reperfusion inJury model of rats. The content of superoxide dismutase(SOD)

malondialdehyde(MDA)

nitrogen monoxide(NO)

Ca2+-ATPase

Na+-K+-ATPase in brain tissue and NO

nerve growth factor (NGF)

vascular endothelial growth factor (VEGF) in serum and hippocampus pathologic changes were observed to research the effect of Qizhi Tongluo Capsule assisted with aspirin. Result: Compared with using aspirin alone

the content of SOD in brain was increased and MDA in brain was reduced significantly by the combination use of Qizhi Tongluo Capsule and aspirin. Meanwhile

NO levels in brain and serum were reduced significantly(P<0.05 or P<0.01)

Ca2+-ATPase

Na+-K+-ATPase in brain tissue and NGF

VEGF in serum were increased significantly(P<0.05 or P<0.01). Conclusion: It played a synergistic role in recovery that Qizhi Tongluo Capsule assisted with aspirin on cerebral ischemia-reperfusion model in rats

and it will be a beneficial assistance to reduce the damage of ischemic.