经血宁胶囊醇提物凝血作用的比较研究

方显明; 谢金鲜; 韩邦志; 霍宇

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经血宁胶囊醇提物凝血作用的比较研究

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- 经血宁胶囊醇提物凝血作用的比较研究
- Comparative Study on Coagulating Action of Water Extract and Alcohol Extract of Jingxuening Capsule
- 中国实验方剂学杂志 2010年16卷第16期页码：140-142
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家科技支撑计划子课题(2006BAI06A18-14)
- DOI：
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- 纸质出版日期：2010
- 稿件说明：
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方显明, 谢金鲜, 韩邦志, 等. 经血宁胶囊醇提物凝血作用的比较研究[J]. 中国实验方剂学杂志, 2010,16(16):140-142.

FANG Xian-ming, XIE Jin-xian, HAN Bang-zhi, et al. Comparative Study on Coagulating Action of Water Extract and Alcohol Extract of Jingxuening Capsule[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 140-142.
方显明, 谢金鲜, 韩邦志, 等. 经血宁胶囊醇提物凝血作用的比较研究[J]. 中国实验方剂学杂志, 2010,16(16):140-142. DOI：

FANG Xian-ming, XIE Jin-xian, HAN Bang-zhi, et al. Comparative Study on Coagulating Action of Water Extract and Alcohol Extract of Jingxuening Capsule[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(16): 140-142. DOI：

摘要

目的: 研究和比较经血宁胶囊醇提物及水提物的凝血作用。方法: 动物随机分成6组

即经血宁醇提物3个剂量组(生药18

9.0

4.5 g ·kg-1)

经血宁水提物组

云南白药组及空白对照组。测定各组凝血时间(CT)

凝血酶时间(TT)

凝血酶元时间(PT)

活化部分凝血活酶时间(APTT)

纤维蛋白原(Fbg)

血小板(PLT)等凝血指标。结果: 与空白对照组比较

经血宁醇提物能明显缩短CT

APTT

血浆复钙时间(PRT)

增加Fbg含量和PLT数量(PP<0.01)。与经血宁水提物比较

经血宁醇提物缩短TT

APTT

PRT的作用优于后者(均P<0.05)。结论: 经血宁醇提物具有显著的凝血作用

其作用强于经血宁水提物。

Abstract

Objective: To study the coagulating action of both extracts(alcohol extract and water extract)of Jingxuening Capsule(JXNC) to find the differences between them. Method: Laboratory animals were randomly divided into six groups

namely blank control group

Yunnan Baiyao powder(YBP) group

JXNC1(extracted by water)and three dosages groups(containing crude drug 18

9.0

4.5 g ·kg-1 respectively)of JXNC2(extracted by alcohol).CT

PTT

APTT

Fbg

PLT and PRT of each group were tested after administration by ig for 5 or 6 days. Result: Compared with blank control group

JXNC 2 groups were able to shorten CT

APTT

PRT

and increase the content of Fbg and PLT significantly.Compared with JXNC 1 group

APTT

PRT of JXNC 2 were shorter than that of the former(P<0.05). Conclusion: JXNC 2(alcobol extract) has good action for blood coagulation

and it is better than JXNC 1(water extract).

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