TANG Hong-qin, ZHOU Wei, NING Tao-li, et al. Antitumor and Apoptosis Inducement Effects of Petroleum Ether Extract from Pine Needles[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 177-179.
TANG Hong-qin, ZHOU Wei, NING Tao-li, et al. Antitumor and Apoptosis Inducement Effects of Petroleum Ether Extract from Pine Needles[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 177-179.DOI:
Objective: To study the antitumor mechanism of petroleum ether extract of pine needles. Method: Antitumor activity of the petroleum ether extract was determined by means of transplantable tumor (S180) in mice. Immunohistochemical methods were employed for detection of Bax
Bcl-2 in tumor tissues. Result: The inhibition rate of peftroleum ether extract2.0 g·(kg·d) -1 on S180-bearing mice was 42.16%. As for 1.0 g·(kg·d) -1 and 0.5 g·(kg·d) -1 groups
the inhibition rates were 41.71% and 31.16%. Expression of Bax in tumors was obviously increased and Bcl-2 was obviously decreased in all the therapy groups compared with the tumor control group (P<0.01). Conclusion: Petroleum ether extract from pinee needles possesses definite antitumor effect.