Objective: To study the effect of Yinxieping Granules on guinea pig model of psoriasis. Method: All guinea pigs were coated propranolol emulsion on the ear twice a day for 2 weeks to establish the model of psoriasis.Then the granules was given daily by oral gavage for 2 weeks.Guinea pigs were sacrificed when the experiment was done.Tumor necrosis factor-α (TNF-α) and cell adhesion molecule (ICAM-1)were determined in the ear homogenates by ELISA kit. Result: Compared with the normal group

TNF-α and ICAM-1 were significantly higher in the model group(P<0.05).Compared with the model group

TNF-α and ICAM-1 were significantly lower in each of the treatment group(P<0.01). Conclusion: Yinxieping granules is a effective treatment for psoriasis.