LIANG Jian-qin, LIU Hua-gang. Distribution of Administrated Resveratrol-loaded Solid Lipid Nanoparticles in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 183-185.
LIANG Jian-qin, LIU Hua-gang. Distribution of Administrated Resveratrol-loaded Solid Lipid Nanoparticles in Mice[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 183-185.DOI:
Objective: To investigate the distribution of resveratrol-loaded solid lipid nonoparticles (Res-SLN) in mice. Method :Res-SLN was prepared by heat-high pressure homogenization method. Distribution studies were accomplished in mice. At different time after tail iv administration at 115.50 mg ·kg-1 for Res-SLN group and at 119.25 mg ·kg-1 for Res-Sus group
the animals were sacrificed (n=5 animals for each time). Tissues were collected
washed
weighted and analyzed. Result: Distribution study in mice demonstrated that Res after administrated Res-SLN was mainly distributed in liver and kidney. Compared to the control group
the target efficiency of Res-SLN was 1.82 folds in kidney. On the other hands
the Res retention time after administrated Res-SLN was prolonged. Conclusion: Res-SLN is an effective preparation that can target Res to kidney in mice.