醒胰降糖灵对实验性糖尿病大鼠血糖及免疫功能的影响

丁文君; 靳锋; 沈明霞; 骆文郁

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醒胰降糖灵对实验性糖尿病大鼠血糖及免疫功能的影响

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- 醒胰降糖灵对实验性糖尿病大鼠血糖及免疫功能的影响
- Effects of Xingyi Jiangtang Ling on Level of Blood Glucose and Immunologic Function in Diabetic Rats
- 中国实验方剂学杂志 2010年16卷第13期页码：180-182
- 作者机构：
- 作者简介：
- 基金信息：
  
  甘肃省教育厅资助项目(0505-07)
- DOI：
  中图分类号：
- 纸质出版日期：2010
- 稿件说明：
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丁文君, 靳锋, 沈明霞, 等. 醒胰降糖灵对实验性糖尿病大鼠血糖及免疫功能的影响[J]. 中国实验方剂学杂志, 2010,16(13):180-182.

DING Wen-jun, JIN Feng, SHEN Ming-xia, et al. Effects of Xingyi Jiangtang Ling on Level of Blood Glucose and Immunologic Function in Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 180-182.
丁文君, 靳锋, 沈明霞, 等. 醒胰降糖灵对实验性糖尿病大鼠血糖及免疫功能的影响[J]. 中国实验方剂学杂志, 2010,16(13):180-182. DOI：

DING Wen-jun, JIN Feng, SHEN Ming-xia, et al. Effects of Xingyi Jiangtang Ling on Level of Blood Glucose and Immunologic Function in Diabetic Rats[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(13): 180-182. DOI：

摘要

目的 :探讨醒胰降糖灵对实验性糖尿病大鼠血糖及免疫功能的影响。方法 :采用高热量饲料加小剂量ip链脲佐菌素(STZ)

并连续sc甲状腺素诱发实验性糖尿病大鼠模型

分别予二甲双胍及醒胰降糖灵进行干预

观测用药后大鼠体重及胸腺和脾脏指数、血糖、胰岛素、胰岛素敏感指数及血清肿瘤坏死因子(TNF-α)、白介素-4(IL-4)的含量。结果 :与正常组比较

模型组大鼠血清TNF-α的含量显著升高(P<0.01)

IL-4的含量显著下降(P<0.01);与模型组比较

醒胰降糖灵治疗组可显著降低血清TNF-α水平(P<0.01)

提高IL-4水平(P<0.01)。结论 :醒胰降糖灵可通过下调Th1型细胞因子(TNF-α)并上调Th2型细胞因子(IL-4)的含量平衡机体的免疫功能。

Abstract

Objective: To explore the effects of Xingyi Jiangtang Ling on blood glucose and immunologic function in diabetic rats. Method: The model of diabetic rat was established by subabdominal injection with streptozotocin 65 mg ·kg-1 and then concomitant hypodemic injection with thyroxine

once a day

from 1th to 7th day. After treated with Xingyi Jiangtang ling for 60 days

the content of TNF-α

IL-4 in the serum of all experimental rats was detected. Result: Compared to normal group

the content of TNF-α in serum of diabetic rats was significantly increased(P<0.01).that of IL-4 was significantly declined. However

the content of TNF-α of treated group was significantly declined

compared with model group(P<0.05). Conclusion: Xingyi Jiangtang Ling can protect immunologic function to β cell in the pancreas by declining TNF-α and increasing of IL-4.It may be one of the mechanisms for antagonizing diabetes.

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