Objective: To investigate the anti-tumor and immune effect of Fuzheng Guben Granule combined with chemotherapy and radiotherapy in tumor-bearing mice. Method: Tumor-bearing model of S180 sarcoma in mice was established by subcutaneous injection of S-180 ascites at armpit. On the next day

the mice were randomly divided into 10 groups

Fuzheng Guben Granule with radio- and chemotherapy was carried out once a day for ten days. Tumor inhibitory percentage

thymus gland

spleen indexes were then measured. The determination of cytokine

such as IL-2

IL-6

TNF-α and peripheral blood cell counts was made. The effect of treatment on tumor inhibition and immunological function was studied. Result: The combined therapy could significantly increase thymus gland

spleen indexes and improved the phagocytic function;antagonize serum IL-2

IL-6 and TNF-α reduction induced by chemotherapy;suppress the decrease in peripheral blood cells count induced by radiotherapy. Conclusion: Combinative therapy can enhance immune functions for S180-bearing mice.