Objective: To observe the effects of Promoting Pedo-digestion Granules (PPD) on the digestion and absorption function and its maximum torerance dose (MTD). Method: The distance of ink moving in small intestine in KM mice was used to evaluate the effect. The mice were randomly divided into treatment groups

control groups and the difenoxin model control group. Treatment groups were fed with 1

2

4 g ·kg-1 dosage accordingly. The body weight

food intakes

food efficiency ratio and the secretion amount of SD rats’gastric juice and pepsin activity were also used to evaluate the effect. The rats were randomly divided into treatment groups and control groups. Treatment groups were fed with dosage as the above. PPD were fed for 30 days. MTD was measured. Result: PPD could increase the rate of ink promoting

which was superior to that in the difenoxin model control group

PPD also could increase the body weight of rats

appetite and food exploitation rate

promote the secretion amount of gastric juice and pepsin

pepsin activity

which was superior to that in the control group. MTD was 56 g ·kg-1 as about 54 times of population recommended amount. Conclusion: PPD has the function of promoting the digestion and absorption function

and oral dose commonly used is safe.