Objective: To investigate the protective effect of the ethanol extract of Ligularia fischeri Ledeb Turcz. in mice on acute alcohol intoxication. Method: We recorded the duration from disappearance of righting reflex (drunk) to restore (hangover) in mice

after given a gavage of 56 degrees liquor. In addition

alcohol-induced liver injury model of mice was established by acute gavage of 52 degrees liquor

and serum alanine aminotransferase (ALT) activity

malondialdehyde (MDA)

triglyceride (TG) content were tested. Activity of glutamic-pyruvic transaminase (ALT)

glutathione peroxidase (GSH-Px)

malondialdehyde (MDA)

triglyceride (TG) in liver tissue was also determined. Result: The ethanol extract of L. fischeri significantly prolonged the incubation period of righting reflex disappeared (drunk) (P<0.05)

reduced hangover time (P<0.05); significantly depressed TG and ALT levels (P<0.05) in serum and liver tissue; and significantly increased GSH-Px activity (P<0.01) in liver tissue. Conclusion: L. fischeri may have a protective effect on acute alcohol intoxication in mice.