Objective: To investigate the effect of Ulinnstatin on the level of serum procalcitonin and IL-6 in patients with urological septic shock. Method: Thirty patients with urological septic shock were randomLy divided into 2 groups-the test group and the control group. The control group accepted the general treatment

such as anti-shock

anti-infection and ICU. The test group accepted Ulfnastandn injection in addition. The levels of serum PCT and IL-6 in 30 patients with urological septic shock were serially measured at different time points by ICA and ELISA. And 20 health controls were included as well. Result: PCT and IL-6 level were significantly higher in patient group than health controls. PCT and IL-6 level in acute phase were higher than in recovery phase andand higher in the death group than in survival group.The PCT and IL-6 level in the test group were significantly lower than in the control group at every selected time points. Conclusion: PCT and IL-6 play important roles in the pathogenesis of sepsis and are valuable for early diagnosis and prognosis. Ulinastatin has protective effect on patients with Urological septic shock.