Objective: To evaluate intranasal administration as one of the ways of brain-targeted drug delivery system. Method: Showing the advantages of nasal administration through building the in vitro model of blood-brain barrier and researching the evaluation methods of drug concentration in brain. Result: The intranasal administration can increase the concentration of drug in the brain so as to accomplish brain-targeted drug delivery. Conclusion: Lack of in-depth understanding of blood-brain barrier is still the major problem existing in the brain-targeted drug delivery system

but with further studies on the transport mechanism of blood-brain barrier

the structural connection between nasal cavity and brain

the pathogenesis in the brain and the pharmacokinetics of brain- targeting drug a breakthrough in the research on brain-targeted drug delivery system can be expected.