ObJective: To observe the intervention effects and mechanism of Bushen Tongluo decoction on bone metabolism and density in the osteoporosis rats. Method :Rat models of the osteoporosis were established by bilateral ovariotomy. The rats were divided into six groups randomLy:the nomal group

model group

XinLinGuBao group

Bushen-based decoction group

Tongluo decoction group

Bushen Tongluo decoction group. After ten weeks treatment

the rats weight

the serum calcium

the serum phosphorus

the serum alkaline phosphatase and the bone density. Result :The weight of the osteoporosis rats increased

the serum calcium decreased

the serum phosphorus increased

the serum alkaline phosphatase increased and the bone density decreased in model group as compared with the normal group(P<0.05).The weight gain of the osteoporosis rats were inhibited in each treat group as compared with model group

but there were no significant difference. The serum calcium increased

the serum phosphorus decreased in each treat group as compared with model group

and there were significant difference in Bushen Tongluo decoction group.The serum alkaline phosphatase decreased obviously in each group as compared with model group(P<0.01).The bone density increased in each group as compared with model group

and there were significant difference in Bushen-based decoction group.(P<0.05) and in Tongluo decoction group and Bushen Tongluo decoction group(P<0.01). The numerus of Bushen Tongluo decoction group were higher than the numerus of Bushen-based decoction group or Tongluo decoction group. Conclusion :Bushen Tongluo decoction group can effectively decrease high dysbolism of bone metabolism

increase bone density in the osteoporosis rats. Bushen decoction and Tongluo decoction have good synergism.