Objective: To study the protective effect of Qingnao Xuanqiao Dropping Pill on acute cerebral ischemia in rats. Method: Intragastric gavage of Qingnao Xuanqiao Dropping Pill (high

medium and low dose)

once a day for three days. The last day animal model of middle cerebral artery occlusion (MCAO) induced by suture-occluded method was adopted. Scoring method of ischemia for 2 h and reperfusion for 22 h was used to evaluate the abnormal behaviour by nerve injury. Radioimmunoassay was used to evaluate NSE activity in serum. HE staining was employed to observe pathological morphology in brain tissue. Result: Each administrated group could improve the nerve defect symptoms of model rats at 6 h and 22 h to some extent. Compared with model group

180 mg ·kg-1 group of Qingnao Xuanqiao Dropping Pill was significantly different (P<0.05); 45

90

180 mg ·kg-1 group of Qingnao Xuanqiao Dropping Pill could reduce NSE activity of the model rats. Pathological results showed the number of normal nerve cells in Qingnao Xuanqiao Dropping Pill group was increased significantly

the scope and the degree of necrotic tissue was reduced. Conclusion: Qingnao Xuanqiao Dropping Pill has a protective effect on cerebral ischemia.