参芪补肺汤对慢性阻塞性肺疾病肺气虚证大鼠肺细胞外基质的影响

张培琴; 张葵; 刘瑶; 陈昱江

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参芪补肺汤对慢性阻塞性肺疾病肺气虚证大鼠肺细胞外基质的影响

更新时间：2024-09-23

- 参芪补肺汤对慢性阻塞性肺疾病肺气虚证大鼠肺细胞外基质的影响
- Effects of Shenqi Bufei Tang on Bronchus Tissue Conformation and Lung Function of Chronic Opstructive Pulmonary Disease Rat Model with Lung-qi Deficiency Syndrome
- 中国实验方剂学杂志 2010年16卷第11期页码：168-170
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- 纸质出版日期：2010
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张培琴, 张葵, 刘瑶, 等. 参芪补肺汤对慢性阻塞性肺疾病肺气虚证大鼠肺细胞外基质的影响[J]. 中国实验方剂学杂志, 2010,16(11):168-170.

ZHANG Pei-qin, ZHANG Kui, LIU Yao, et al. Effects of Shenqi Bufei Tang on Bronchus Tissue Conformation and Lung Function of Chronic Opstructive Pulmonary Disease Rat Model with Lung-qi Deficiency Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 168-170.
张培琴, 张葵, 刘瑶, 等. 参芪补肺汤对慢性阻塞性肺疾病肺气虚证大鼠肺细胞外基质的影响[J]. 中国实验方剂学杂志, 2010,16(11):168-170. DOI：

ZHANG Pei-qin, ZHANG Kui, LIU Yao, et al. Effects of Shenqi Bufei Tang on Bronchus Tissue Conformation and Lung Function of Chronic Opstructive Pulmonary Disease Rat Model with Lung-qi Deficiency Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(11): 168-170. DOI：

摘要

目的 :观察参芪补肺汤对慢性阻塞性肺疾病(COPD)肺气虚证大鼠肺细胞外基胶原和纤维连接蛋白(FN)的影响。方法: 用烟、SO2定量熏吸并复合木瓜蛋白酶雾化吸入法

建立COPD肺气虚证大鼠模型;60只雄性Wistar大鼠随机分为正常组、模型组、参芪补肺汤高、中、低剂量组、激素组;肺Masson染色观察胶原纤维的分布情况;放射免疫法检测支气管肺泡灌洗液(BALF)中FN的含量。结果: 与正常组比较

模型组支气管肺组织单位面积内胶原面积和积分吸光度(IA)显著增加( P ≤0.01);BALF中FN的含量显著增加( P <0.01)。经治疗后

与模型组比较

参芪补肺汤高、中剂量组胶原面积和积分吸光度(IA)显著降低(P<0.05);FN含量显著减少(P<0.01)。结论: 参芪补肺汤可能通过抑制COPD肺气虚证大鼠肺细胞外基质的过度沉积

而对阻止COPD气道重构有一定作用。

Abstract

Objective: To observe the effects of Shenqi Bufei Tang on collagen deposition and fibronectin (FN) of COPD rat model with lung-qi deficiency syndrome. Method: COPD rat model with lung-qI deficiency syndrome was established by quantitative stimulation with tobacco

SO2 and papain.Sixty male rats were randomly divided into 6 groups: normal group

model group

low dose treatment group

medium dose treatment group

high dose treatment group

and glucocorticoid treatment group. Collagen deposition in Masson stained slides was observed under light microscope and expression of collagen was determined by computer image analyzer. The contents of FN in the BALF were tested by radioimmunoassay. Result: The expressions of collagen in small brouch and lung tissue and the contents of FN in the BALF of the model group were significanthly higher than those of the normol group(P<0.01). After treatment

the expressions of collagen and the contents of FN in the BALF in the high and middle dose group were remarkably decreased than those in the modle group (P<0.01). Conclusion: Shenqi Bufei Tang may inhibit the deposition of collagen and fibronectin

influence airway remodeling of COPD rat model with lung-qi deficiency syndrome.

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